Update on the Genetic Research at the University of Massachusetts
By Robert H. Brown, Jr., D.Phil., M.D.
Activity Report – Day Lab – U Mass Medical School
The Day Lab at UMMS has had another strong year of HSAN1 research. First, we have enjoyed collaborating with Florian Eichler at the Mass General Hospital to see the serine trial move toward completion. Second, we have continued to work on the use of small DNA molecules (oligonucleotides) to silence the HSAN1 gene. This work represents the efforts of a graduate student, Ms. Havisha Karnam, with an outstanding faculty member, Dr. Anastasia Khvorova. Dr. Khvorova has patented several new types of DNA molecules to silence genes and has made three of these available for our work on HSAN1.
Third, in a parallel project, we are working on an entirely different approach to silencing the mutant SPT (the enzyme serine palmitoyltransferase) gene using non-toxic, adeno-associated viruses to deliver a different type of silencing element into the spinal cord and dorsal root ganglia.
Finally, starting in August we will have a new post-doctoral fellow on our team who has prior experience studying the HSAN1 gene (the SPT gene). She will participate in these experiments as one component of her overall fellowship program.